Saturday, December 1, 2018

The FDA just approved a drug that targets cancers based on DNA, rather than where the tumor is in your body

The FDA just approved a drug that targets cancers based on DNA, rather than where the tumor is in your body

cancer cells
A tray containing cancer cells sits on an optical microscope in the Nanomedicine Lab at UCL's School of Pharmacy in London.
REUTERS/Suzanne Plunkett
  • The FDA on Monday approved a new cancer treatment in an unconventional way: not by tumor type, but rather by the genetic mutation the drug targets.
  • The drug, Vitrakvi, was developed by Loxo Oncology in partnership with pharma giant Bayer.
  • It's only the second time the FDA has approved a cancer drug's use based on a certain mutation rather than a particular tumor type.
The Food and Drug Administration on Monday took an unconventional approach to approving a new cancer drug.
The drug, Vitrakvi, was developed by Loxo Oncology. It's the company's first drug to get approved.
Loxo's approach is to develop drugs that act on cancerous genetic mutations rather than the type of cancer a person has. For example, Vitrakvi, has been tested in patients with lung, colon, breast and thyroid cancer among others.
The drug comes with a high price tag of $393,000 a year. Bayer said in a statement that there's between 2,500 and 3,000 new patients with this mutation a year. The company set a lower price of $132,000 a year for the liquid form used in pediatric cases. Bayer said it will offer financial assistance to help patients afford the drug, reducing the out-of-pocket cost to $20 a month for most patients.
"Today's approval marks another step in an important shift toward treating cancers based on their tumor genetics rather than their site of origin in the body," FDA Commissioner Scott Gottlieb said in a news release Monday.
In 2017, the drugmaker struck a $1.5 billion deal with pharma giant Bayer to commercialize and develop two of Loxo's drugs, including Vitrakvi.

Targeting a genetic mutation instead of cancer type

Building a treatment that's specific to a genetic mutation is a new approach to treating cancer. Most companies develop treatments for specific types of cancer, like lung cancer or melanoma, and seek approval just for that one kind of tumor at first, before setting up more trials to see how the drug does in other types of cancer.
Scientists have seen genetic patterns across cancer types for years, but the topic started attracting more attention in 2013 after the discovery that endometrial cancer was genetically similar to forms of ovarian and breast cancer.
In May 2017, the FDA approved a drug based on genetics rather than tissue type for the first time, paving the way for others including Loxo.
Loxo's drug works in cancer patients with a mutation called a "TRK gene fusion."
The company had seen promising results in its human trials. In a recent presentation at the European Society for Medical Oncology, Loxo said that out of 109 patients, 81% had an overall response rate, meaning their tumors shrank. In 17% of the cases, the patients had a complete response, meaning their tumors went away entirely. 

source :  https://www.businessinsider.com/fda-approves-loxo-oncologys-larotrectinib-vitrakvi-2018-11

Vitrakvi Un nouveau traitement du cancer basé sur la génétique, commercialisé aux USA

Un nouveau traitement du cancer basé sur la génétique, commercialisé aux USA
 
L'agence sanitaire américaine FDA (Food and Drug Administration) a approuvé, mardi 26 novembre, un médicament destiné au traitement des tumeurs présentant un changement génétique spécifique. 
C'est la deuxième fois que la FDA approuve un traitement du cancer basé sur un biomarqueur commun à différents types de tumeurs plutôt que sur l'emplacement dans le corps d'où provient la tumeur.  Vitrakvi (Larotrectinib) est indiqué dans le traitement des adultes et enfants atteints de tumeurs solides à test positif pour les gènes NTRK, ce qui peut favoriser la croissance des tumeurs cancéreuses. Les tumeurs présentant ce type de modification génétique ne sont pas courantes, mais peuvent être retrouvées dans les cancers des sarcomes des glandes salivaires, de la thyroïde, des poumons et des tissus mous.
Le médicament doit être utilisé pour traiter les tumeurs qui se sont propagées ou qui n’ont pas pu être enlevées chirurgicalement et qui se sont développées au cours de traitements antérieurs.
L'efficacité du Larotrectinib a été étudiée dans le cadre de trois essais cliniques, portant sur 55 patients adultes et enfants, tous atteints de tumeurs positives pour NTRK.
Le traitement a montré un taux de réponse global de 75% pour différents types de tumeurs solides. 73% des réponses ont duré au moins six mois et 39% ont duré un an ou plus au moment de l’analyse des résultats.
En 2017, la FDA a élargi l’approbation de Keytruda (pembrolizumab) afin d’inclure le traitement des adultes et des enfants atteints de tumeurs solides avancées présentant des niveaux élevés d’instabilité microsatellite (MSI-H) ou de déficience de réparation de mismatch (MMR).
La FDA a approuvé l'homologation de Vitrakvi à Loxo OncologyIl sera vendu au prix de 32.800 dollars par mois, en partenariat avec Bayer.

طرح أول دواء يعالج مرض السرطان من منبعه Vitrakvi




طرح أول دواء يعالج مرض السرطان من منبعه

أعلنت هيئة الغذاء والدواء الأميركية (FDA)، عن إجازة أول دواء في العالم يمكنه معالجة مرض السرطان من منبعه وأصله وللكبار والصغار، بحسب ما أفاد مفوض الهيئة الحكومية.
ويعتمد عقار"فيتراكفي" (Vitrakvi)، على معالجة الطفرات الوراثية للأورام السرطانية،بغض النظر عن نوع المرض أو مكان نشأته.
وقال مفوض الهيئة الأميركية سكوت غوتليب، إن "التصديق على إجازة وطرح هذا الدواء، خطوة مهمة لعلاج السرطان، لأنه يعالجه من منبعه، ويعالج أساس جينات الأورام السرطانية أيا كان موقع منشأها في جسم الإنسان".
وأكد غوتليب، أن العقار الجديد سوف يساعد مرضى السرطان للحصول على العلاج المناسب، ويساهم عقار "فيتراكفي" في علاج أشخاص يعانون من أورام سرطانية مختلفة، ولكن يمتلكون طفرات وراثية مشتركة.
وقال رئيس مركز تطوير الأدوية المبكر في مركز ميمورال، سلوان كيترينج للسرطان في نيويورك، الدكتور ديفيد هايمان "تقليديا كان يتم علاج السرطان بناء على أساس مصدر الورم السرطاني، لكن حاليا سيكون العلاج لأي مكان في الجسم لأنك تعالج الجين الأصلي الذي تسبب في ظهور الورم".
وتم تجربة الدواء فعلياً على البشر، وسجلت حالة شفاء طفلة خلال أشهر بعد تناول الدواء، وسوف يطرح الدواء على هيئتين، الأولى في هيئة أقراص أو كبسولات، والأخرى على هيئة دواء شراب للأطفال بشكل خاص.
المصدر (سكاي نيوز)

Wednesday, April 18, 2018

mosaic letter coloring privacy policy

Download mosaic letter coloring

Amdroid Solari built mosaic letter coloring as a Free game. This SERVICE is provided by Amdroid Solari at no cost and is intended for use as is.


This page is used to inform website visitors regarding my policies with the collection, use, and disclosure of Personal Information if anyone decided to use my Service.
If you choose to use my Service, then you agree to the collection and use of information in relation to this policy. The Personal Information that I collect is used for providing and improving the Service. I will not use or share your information with anyone except as described in this Privacy Policy.
The terms used in this Privacy Policy have the same meanings as in our Terms and Conditions, which is accessible at smorfy jump unless otherwise defined in this Privacy Policy.
Information Collection and Use
For a better experience, while using our Service, I may require you to provide us with certain personally identifiable information. The information that I request is retained on your device and is not collected by me in any way
The app does use third party services that may collect information used to identify you.
Link to privacy policy of third party service providers used by the app
Log Data
I want to inform you that whenever you use my Service, in a case of an error in the app I collect data and information (through third party products) on your phone called Log Data. This Log Data may include information such as your device Internet Protocol (“IP”) address, device name, operating system version, the configuration of the app when utilizing my Service, the time and date of your use of the Service, and other statistics.
Cookies
Cookies are files with small amount of data that is commonly used an anonymous unique identifier. These are sent to your browser from the website that you visit and are stored on your device internal memory.
This Service does not use these “cookies” explicitly. However, the app may use third party code and libraries that use “cookies” to collection information and to improve their services. You have the option to either accept or refuse these cookies and know when a cookie is being sent to your device. If you choose to refuse our cookies, you may not be able to use some portions of this Service.
Service Providers
I may employ third-party companies and individuals due to the following reasons:
  • To facilitate our Service;
  • To provide the Service on our behalf;
  • To perform Service-related services; or
  • To assist us in analyzing how our Service is used.
I want to inform users of this Service that these third parties have access to your Personal Information. The reason is to perform the tasks assigned to them on our behalf. However, they are obligated not to disclose or use the information for any other purpose.
Security
I value your trust in providing us your Personal Information, thus we are striving to use commercially acceptable means of protecting it. But remember that no method of transmission over the internet, or method of electronic storage is 100% secure and reliable, and I cannot guarantee its absolute security.
Links to Other Sites
This Service may contain links to other sites. If you click on a third-party link, you will be directed to that site. Note that these external sites are not operated by me. Therefore, I strongly advise you to review the Privacy Policy of these websites. I have no control over and assume no responsibility for the content, privacy policies, or practices of any third-party sites or services.
Children’s Privacy
These Services do not address anyone under the age of 13. I do not knowingly collect personally identifiable information from children under 13. In the case I discover that a child under 13 has provided me with personal information, I immediately delete this from our servers. If you are a parent or guardian and you are aware that your child has provided us with personal information, please contact me so that I will be able to do necessary actions.
Changes to This Privacy Policy
I may update our Privacy Policy from time to time. Thus, you are advised to review this page periodically for any changes. I will notify you of any changes by posting the new Privacy Policy on this page. These changes are effective immediately after they are posted on this page.
Contact Us
If you have any questions or suggestions about my Privacy Policy, do not hesitate to contact me at abidinemariem@gmail.com 

Wednesday, April 11, 2018

ballon in bucket android game privacy policy

Download ballon in bucket

Amdroid Solari built Santa Christmas Call  app as a Free app. This SERVICE is provided by Amdroid Solari at no cost and is intended for use as is.

This page is used to inform website visitors regarding my policies with the collection, use, and disclosure of Personal Information if anyone decided to use my Service.
If you choose to use my Service, then you agree to the collection and use of information in relation to this policy. The Personal Information that I collect is used for providing and improving the Service. I will not use or share your information with anyone except as described in this Privacy Policy.
The terms used in this Privacy Policy have the same meanings as in our Terms and Conditions, which is accessible at smorfy jump unless otherwise defined in this Privacy Policy.
Information Collection and Use
For a better experience, while using our Service, I may require you to provide us with certain personally identifiable information. The information that I request is retained on your device and is not collected by me in any way
The app does use third party services that may collect information used to identify you.
Link to privacy policy of third party service providers used by the app
Log Data
I want to inform you that whenever you use my Service, in a case of an error in the app I collect data and information (through third party products) on your phone called Log Data. This Log Data may include information such as your device Internet Protocol (“IP”) address, device name, operating system version, the configuration of the app when utilizing my Service, the time and date of your use of the Service, and other statistics.
Cookies
Cookies are files with small amount of data that is commonly used an anonymous unique identifier. These are sent to your browser from the website that you visit and are stored on your device internal memory.
This Service does not use these “cookies” explicitly. However, the app may use third party code and libraries that use “cookies” to collection information and to improve their services. You have the option to either accept or refuse these cookies and know when a cookie is being sent to your device. If you choose to refuse our cookies, you may not be able to use some portions of this Service.
Service Providers
I may employ third-party companies and individuals due to the following reasons:
  • To facilitate our Service;
  • To provide the Service on our behalf;
  • To perform Service-related services; or
  • To assist us in analyzing how our Service is used.
I want to inform users of this Service that these third parties have access to your Personal Information. The reason is to perform the tasks assigned to them on our behalf. However, they are obligated not to disclose or use the information for any other purpose.
Security
I value your trust in providing us your Personal Information, thus we are striving to use commercially acceptable means of protecting it. But remember that no method of transmission over the internet, or method of electronic storage is 100% secure and reliable, and I cannot guarantee its absolute security.
Links to Other Sites
This Service may contain links to other sites. If you click on a third-party link, you will be directed to that site. Note that these external sites are not operated by me. Therefore, I strongly advise you to review the Privacy Policy of these websites. I have no control over and assume no responsibility for the content, privacy policies, or practices of any third-party sites or services.
Children’s Privacy
These Services do not address anyone under the age of 13. I do not knowingly collect personally identifiable information from children under 13. In the case I discover that a child under 13 has provided me with personal information, I immediately delete this from our servers. If you are a parent or guardian and you are aware that your child has provided us with personal information, please contact me so that I will be able to do necessary actions.
Changes to This Privacy Policy
I may update our Privacy Policy from time to time. Thus, you are advised to review this page periodically for any changes. I will notify you of any changes by posting the new Privacy Policy on this page. These changes are effective immediately after they are posted on this page.
Contact Us
If you have any questions or suggestions about my Privacy Policy, do not hesitate to contact me at abidinemariem@gmail.com 

Monday, March 26, 2018

Miner santa game privacy policy

Miner Santa

Amdroid Solari built Miner santa  app as a Free app. This SERVICE is provided by Amdroid Solari at no cost and is intended for use as is.


This page is used to inform website visitors regarding my policies with the collection, use, and disclosure of Personal Information if anyone decided to use my Service.
If you choose to use my Service, then you agree to the collection and use of information in relation to this policy. The Personal Information that I collect is used for providing and improving the Service. I will not use or share your information with anyone except as described in this Privacy Policy.
The terms used in this Privacy Policy have the same meanings as in our Terms and Conditions, which is accessible at smorfy jump unless otherwise defined in this Privacy Policy.
Information Collection and Use
For a better experience, while using our Service, I may require you to provide us with certain personally identifiable information. The information that I request is retained on your device and is not collected by me in any way
The app does use third party services that may collect information used to identify you.
Link to privacy policy of third party service providers used by the app
Log Data
I want to inform you that whenever you use my Service, in a case of an error in the app I collect data and information (through third party products) on your phone called Log Data. This Log Data may include information such as your device Internet Protocol (“IP”) address, device name, operating system version, the configuration of the app when utilizing my Service, the time and date of your use of the Service, and other statistics.
Cookies
Cookies are files with small amount of data that is commonly used an anonymous unique identifier. These are sent to your browser from the website that you visit and are stored on your device internal memory.
This Service does not use these “cookies” explicitly. However, the app may use third party code and libraries that use “cookies” to collection information and to improve their services. You have the option to either accept or refuse these cookies and know when a cookie is being sent to your device. If you choose to refuse our cookies, you may not be able to use some portions of this Service.
Service Providers
I may employ third-party companies and individuals due to the following reasons:
  • To facilitate our Service;
  • To provide the Service on our behalf;
  • To perform Service-related services; or
  • To assist us in analyzing how our Service is used.
I want to inform users of this Service that these third parties have access to your Personal Information. The reason is to perform the tasks assigned to them on our behalf. However, they are obligated not to disclose or use the information for any other purpose.
Security
I value your trust in providing us your Personal Information, thus we are striving to use commercially acceptable means of protecting it. But remember that no method of transmission over the internet, or method of electronic storage is 100% secure and reliable, and I cannot guarantee its absolute security.
Links to Other Sites
This Service may contain links to other sites. If you click on a third-party link, you will be directed to that site. Note that these external sites are not operated by me. Therefore, I strongly advise you to review the Privacy Policy of these websites. I have no control over and assume no responsibility for the content, privacy policies, or practices of any third-party sites or services.
Children’s Privacy
These Services do not address anyone under the age of 13. I do not knowingly collect personally identifiable information from children under 13. In the case I discover that a child under 13 has provided me with personal information, I immediately delete this from our servers. If you are a parent or guardian and you are aware that your child has provided us with personal information, please contact me so that I will be able to do necessary actions.
Changes to This Privacy Policy
I may update our Privacy Policy from time to time. Thus, you are advised to review this page periodically for any changes. I will notify you of any changes by posting the new Privacy Policy on this page. These changes are effective immediately after they are posted on this page.
Contact Us
If you have any questions or suggestions about my Privacy Policy, do not hesitate to contact me at abidinemariem@gmail.com 

Sunday, March 18, 2018

Surprise egg

Amdroid Solari built surprise egg  app as a Free app. This SERVICE is provided by Amdroid Solari at no cost and is intended for use as is.


This page is used to inform website visitors regarding my policies with the collection, use, and disclosure of Personal Information if anyone decided to use my Service.
If you choose to use my Service, then you agree to the collection and use of information in relation to this policy. The Personal Information that I collect is used for providing and improving the Service. I will not use or share your information with anyone except as described in this Privacy Policy.
The terms used in this Privacy Policy have the same meanings as in our Terms and Conditions, which is accessible at smorfy jump unless otherwise defined in this Privacy Policy.
Information Collection and Use
For a better experience, while using our Service, I may require you to provide us with certain personally identifiable information. The information that I request is retained on your device and is not collected by me in any way
The app does use third party services that may collect information used to identify you.
Link to privacy policy of third party service providers used by the app
Log Data
I want to inform you that whenever you use my Service, in a case of an error in the app I collect data and information (through third party products) on your phone called Log Data. This Log Data may include information such as your device Internet Protocol (“IP”) address, device name, operating system version, the configuration of the app when utilizing my Service, the time and date of your use of the Service, and other statistics.
Cookies
Cookies are files with small amount of data that is commonly used an anonymous unique identifier. These are sent to your browser from the website that you visit and are stored on your device internal memory.
This Service does not use these “cookies” explicitly. However, the app may use third party code and libraries that use “cookies” to collection information and to improve their services. You have the option to either accept or refuse these cookies and know when a cookie is being sent to your device. If you choose to refuse our cookies, you may not be able to use some portions of this Service.
Service Providers
I may employ third-party companies and individuals due to the following reasons:
  • To facilitate our Service;
  • To provide the Service on our behalf;
  • To perform Service-related services; or
  • To assist us in analyzing how our Service is used.
I want to inform users of this Service that these third parties have access to your Personal Information. The reason is to perform the tasks assigned to them on our behalf. However, they are obligated not to disclose or use the information for any other purpose.
Security
I value your trust in providing us your Personal Information, thus we are striving to use commercially acceptable means of protecting it. But remember that no method of transmission over the internet, or method of electronic storage is 100% secure and reliable, and I cannot guarantee its absolute security.
Links to Other Sites
This Service may contain links to other sites. If you click on a third-party link, you will be directed to that site. Note that these external sites are not operated by me. Therefore, I strongly advise you to review the Privacy Policy of these websites. I have no control over and assume no responsibility for the content, privacy policies, or practices of any third-party sites or services.
Children’s Privacy
These Services do not address anyone under the age of 13. I do not knowingly collect personally identifiable information from children under 13. In the case I discover that a child under 13 has provided me with personal information, I immediately delete this from our servers. If you are a parent or guardian and you are aware that your child has provided us with personal information, please contact me so that I will be able to do necessary actions.
Changes to This Privacy Policy
I may update our Privacy Policy from time to time. Thus, you are advised to review this page periodically for any changes. I will notify you of any changes by posting the new Privacy Policy on this page. These changes are effective immediately after they are posted on this page.
Contact Us
If you have any questions or suggestions about my Privacy Policy, do not hesitate to contact me at abidinemariem@gmail.com